Showing posts with the label Sean Curran

Binge on sugars and yet stay fit [Coffee-byte]

Image credit: Imagine a life where you could eat all the sweets, chocolates and junk food in the world and not bother about putting on weight. Well, it is not some weight loss diet or a strict exercise regime that we are promoting. This is you leading your normal life, going to work, lazying on weekends, spending time with your family and friends, but with one additional mutation inducted in your Nrf2 gene .  While this is far from reality for humans, at least in the near future, roundworms in Dr. Sean Curran 's lab at the University of Southern California are enjoying this life style even today right now even as you read this post. This happening because the roundworms ( Caenorhabditis elegans ) carry a mutated version of the SKN-1 gene, which makes it hyperactive. The excess activity of the gene allows the worms to eat a high sugar diet and still not gain any weight while regular worms that do not carry the mutation became obese on a similar diet. 

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