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Showing posts with the label Obesity

Obesity does not damage your knees, microbes do!

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Damage to the knees, or osteoarthritis, is commonly seen in people who are obese. For many years, it was assumed that osteoarthritis is due to additional stress on the knee joints, due to increased weight. However, studies have shown that the commonly seen side effect of obesity is actually due to the increase in systemic and local inflammation caused by macrophages and other inflammatory cells that are targeting the adipose tissue but the joints tissue are caught in the cross fire and undergo degeneration. 
Studies published over the last couple of years have now been able to associate the inflammation seen in obesity to the gut microbiome. While this might sound a bit outlandish, researchers studying the gut microbiomes have found that nature of microbiome of the gut is dependent primarily on the dietary intake. Nature of food intake can distort the natural flora of the gut, which can then effect the inflammatory status in the body, leading to events like osteoarthritis in obesity,…

Leptin can help you lose weight?

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Leptin is a small hormone produced by the adipose tissues (fat cells) in our body and functions as a signal for the amount of fat present in the body. Depending on the 'Leptin' signal received, the brain can instruct our stomach to stop demanding food or our mouth to stop eating, thereby reducing food intake. So, in theory, more the amount of leptin in your body, lesser will you eat and it would be a a breeze to keep your weight in control. Of course, there is a catch.
The effect of Leptin was discovered in 1994 in a study involving voraciously eating obese mice. When these mice were given leptin injections, their craving for food dropped and they returned to normal body weight. So, scientists attempted to cure obesity in humans with the help of leptin injections. But, during trials, large amounts and frequent doses of leptin had to be injected to gain significant weight loss in highly obese patients. Also, large doses resulted in redness of skin at the site of injection for c…

Eating - from casual to compulsive

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In a world where we are battling addiction of some sort or the other, food is another item that has made the list. With the rising number of obese people around, scientists are looking for answer to questions that come up with eating, and one question that has made it to the fore is; when does the habit of eating move from being casual to compulsive. 
To answer this question scientists had to dig deeper and look at the relationship that food has with not only our body, but also with our brain. What they found was nothing short of astonishing. Eating, it seems, is not very different from addiction to drugs. Our brain has opioid receptors that are receptive to opiates (substances such as heroin, morphine etc.) These molecules play an important role in motivation, emotional attachment, satisfaction etc. Our body produces similar proteins as well, which are known as endorphins or endogenous morphine. These neurotransmitters are produced during excitement, love, orgasm, exercise and surpr…