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Showing posts with the label Diabetes mellitus type 2

Genetic Mutation helps Amish live longer, healthier!

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Genetic mutations are usually associated with bad news. A mutation in BRCA genes could put you at risk of breast or ovarian cancer or give you a blood disorder like thalassemia or haemophilia. From cystic fibrosis to phenylketonuria, colour blindness to polycystic kidney, there is a long list (some rare, some not so rare) of diseases caused by mutations. 

Although, Marvel Comics has done a lot on its part to promote the good that can come out of harboring a rare mutation, the benefits are yet to reach the common man. A commonly cited example for good mutation is the resistance to malaria that is conferred by the Sickle Cell mutation, but it does come with the risk of getting two copies of the mutation and being affected by sickled red blood cells. There are a few other mutations that seem to help people lower their risk for heart diseases, get stronger bones or improve their under water vision.
But, a recently published paper in Science Advances puts light on a mutation in SERPINE1 gene …

RotM: Interview with Dr. Suresh Thareja & Dr. Sant Kumar Verma

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For this edition of Researcher of the Month (RotM), we interviewed researchers Dr. Suresh Thareja and research fellow Sant Kumar Verma from Guru Ghasidas Central University located in Bilaspur, Chattisgarh, India.  Dr Thareja is the assistant professor for Pharmaceutical Chemistry in the School of Pharmaceutical Sciences at Ghasidas Central University and currently visiting scholar at the Georgia State University, USA. Mr. Sant Kumar Verma is the senior research fellow at the University working on management of diabetic complications. His research is being funded by the Indian Council of Medical Research (ICMR). 

Aldose reductase (AR) is an important enzyme since it converts glucose to sorbitol and begins the metabolism of glucose in the body. In patients, with diabetes, the body faces a hyperglycemic condition, which prompts the cells to make high amounts of AR, thereby producing high amounts of sorbitol which is impermeable in the cells and causes osmotic stress. Additionally, AR als…