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Showing posts from May, 2018

Use CaRROT to turn on/off genes

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Genetic modification is a hugely debated subject as well as a highly interesting one. Being able to genetically modify a plant or an animal (humans included) is a huge achievement towards understanding our genes and their function. Over the past few years, CRISPR- Cas9 has been in the news for the simple reason that the technology allows labs to easily edit genomic sequences in live cells. The simplicity of the technique lies in the fact it requires a CRISPR associated protein 9 (Cas 9) and a single guide RNA (gRNA) to edit the region of your interest. 
The technology also brings with it the promise of curing genetic diseases like sickle cell anemia, beta-thalassemia and cystic fibrosis, among others. Many privately funded labs are already in the race to design and manufacture CRISPR-Cas9 derived therapeutics that could make genetic diseases a thing of the past.CRISPR-Cas9, however, has its limitations. For one, the editing that it can easily bring about, is not very specific,…